background:
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DSF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.
Tissue specificity: Highly expressed in testis and thymus. Expressed also in most cancer cells lines.
Function:
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DSF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.
Subunit:
Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DSF4A or DSF4B. Such complexes are stable upon replication stress. Interacts with MEN1, MCM2, ORC2, ORC4 and ORC6.
Subcellular Location:
Nucleus.
Tissue Specificity:
Highly expressed in testis and thymus. Expressed also in most cancer cells lines.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Contains 2 BRCT domains.
Contains 1 DSF4-type zinc finger.
Database links:
UniProtKB/Swiss-Prot: Q9UBU7.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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