background:
CDCA3 (Cell division cycle associated 3) is an F-box-like protein which is required for entry into mitosis. It is associated with SKP1 as part of a SCF (SKP1-cullin-F-box) protein ligase complex, and is required for the ubiquitination and degradation of the CDK1 inhibitory tyrosine kinase WEE1 at G2/M phase.
Function:
F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity).
Subunit:
Protein modification; protein ubiquitination.
[SUBUNIT] Interacts with SKP1. Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity).
Subcellular Location:
Cytoplasm, cytosol (By similarity).
Post-translational modifications:
Ubiquitinated and degraded by the APC/SLCCdh1 complex (By similarity).
Phosphorylated upon DNA damage, probably by ATM or ATR.
Database links:
UniProtKB/Swiss-Prot: Q99618.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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