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Rabbit Anti-AIMP3/FITC Conjugated antibody
background:
This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]
Function:
Positive modulator of ATM response to DNA damage.
Subunit:
Component of the multisynthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Interacts with ATM and ATR. The interaction with ATM, which takes place independently of TP53, is induced by DNA damage that may occur during genotoxic stress or cell growth. The interaction with ATR is enhanced by UV irradiation
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Down-regulated in various cancer tissues.
Similarity:
Contains 1 GST SLCterminal domain.
Database links:
Entrez Gene: 9521 Human
Entrez Gene: 66143 Mouse
Omim: 609206 Human
SwissProt: O43324 Human
SwissProt: Q9D1M4 Mouse
Unigene: 602353 Human
Unigene: 726163 Human
Unigene: 36683 Mouse
Unigene: 490319 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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