background:
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II).
Function:
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II).
Subunit:
Associates with CDK9 to form P-TEFb. Isoform 1 and isoform 2 interact with HISLV2 and SIV Tat. Does not bind efficiently to the transactivation domain of the HISLV1 Tat.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitously expressed.
Similarity:
Belongs to the cyclin family. Cyclin C subfamily.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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