Home
>
Product
>
Antibody
>
Rabbit Anti-Iroquois homeobox protein 3/FITC Conjugated antibody
background:
Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells.
Function:
Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity).
Subunit:
Belongs to the TALE/IRO homeobox family.
Contains 1 homeobox DNA-binding domain.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the TALE/IRO homeobox family.
Contains 1 homeobox DNA-binding domain.
Database links:
UniProtKB/Swiss-Prot: P78415.3
Entrez Gene: 79191 Human
Entrez Gene: 16373 Mouse
Omim: 612985 Human
SwissProt: P78415 Human
SwissProt: P81067 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|