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Rabbit Anti-GPSM1/FITC Conjugated antibody
background:
Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.
Function:
Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.
Subunit:
Interacts with GNAI1, GNAI2 and GNAI3 preferentially in their GDP-bound state. May also interact with GNAO1. Interacts with STK11/LKB1 and MACF1 (By similarity). Interacts with INSC/inscuteable and FRMPD1.
Subcellular Location:
Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Tissue Specificity:
Expressed in intestinal cells.
Post-translational modifications:
Phosphorylation regulates interaction with G(i/o) alpha.
Similarity:
Belongs to the GPSM family.
Contains 4 GoLoco domains.
Contains 9 TPR repeats.
Database links:
Entrez Gene: 26086 Human
Entrez Gene: 67839 Mouse
Entrez Gene: 246254 Rat
Omim: 609491 Human
SwissProt: Q86YR5 Human
SwissProt: Q6IR34 Mouse
SwissProt: Q9R080 Rat
Unigene: 239370 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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