background:
Delta-like 3 (DLL3) is a transmembrane Delta-like protein that inhibits primary neurogenesis. It may be required to divert neurons along a specific differentiation pathway and plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 is one of five DSL proteins that bind to the Notch receptor and activates Notch signaling.
Function:
Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
Subunit:
Can bind and activate Notch-1 or another Notch receptor (Probable).
Subcellular Location:
Membrane; Single-pass type I membrane protein (Probable).
Tissue Specificity:
Predominantly expressed in the neuroectoderm and paraxial mesoderm during embryogenesis.
Post-translational modifications:
Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.
DISEASE:
Note=A truncating mutation in Dll3 is the cause of the pudgy (pu) phenotype. Pudgy mice exhibit patterning defects at the earliest stages of somitogenesis. Adult pudgy mice present severe vertebral and rib deformities.
Similarity:
Contains 1 DSL domain.
Contains 6 EGF-like domains.
Database links:
Entrez Gene: 505993 Cow
Entrez Gene: 10683 Human
Entrez Gene: 100520433 Pig
Omim: 602768 Human
SwissProt: Q9NYJ7 Human
Unigene: 127792 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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