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Rabbit Anti-CEND1/FITC Conjugated antibody
background:
BM88 is a 149 amino acid protein that belongs to the CEND1 familly. Involved in neuroblastoma cell differentiation, BM88 is a single-pass type IV membrane protein that is neuron specific. It is suggested that BM88 forms a dimer of two identical polypeptides linked by disulfide bridges. BM88 has a central proline-rich region containing four PxxP motifs, which typically bind SRC homology-3 (SH3) domains, as well as a putative SLCterminal transmembrane region, and several potential sites for N-glycosylation, myristoylation and phosphorylation. It is also suggested that a novel signaling mechanism exists by which BM88 interferes with calcium release from inositol 1,4,5-trisphosphate-sensitive stores and exerts anti-proliferative and anti-apoptotic functions. BM88 is an important molecular target for HDAC inhibition, and transcription of BM88 is induced by trichostatin-A.
Function:
CEND1 is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene.
Subunit:
Homodimer
Subcellular Location:
Membrane; Single-pass type IV membrane protein.
Tissue Specificity:
Neuron specific.
Similarity:
Belongs to the CEND1 family.
Database links:
Entrez Gene: 51286 Human
Entrez Gene: 57754 Mouse
Entrez Gene: 361675 Rat
Omim: 608213 Human
SwissProt: Q8N111 Human
SwissProt: Q9JKC6 Mouse
SwissProt: Q5FVI4 Rat
Unigene: 22140 Human
Unigene: 87027 Mouse
Unigene: 6492 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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