background:
This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis. [provided by RefSeq, Dec 2011].
BMPER is a BMP-binding protein that is expressed by endothelial cell precursors, has BMP-antagonizing activity, and may play a role in endothelial cell differentiation by modulating local BMP activity. It may also regulate BMP responsiveness in osteoblasts and chondrocytes.
Subunit:
Interacts with BMP4.
Subcellular Location:
Secreted.
Tissue Specificity:
Highly expressed in lung, and brain and also in primary chondrocytes.
Similarity:
Contains 1 TIL (trypsin inhibitory-like) domain. Contains 5 VWFC domains. Contains 1 VWFD domain.
Database links:
Entrez Gene: 168667 Human
Entrez Gene: 73230 Mouse
Entrez Gene: 300455 Rat
Omim: 608699 Human
SwissProt: Q8N8U9 Human
SwissProt: Q8CJ69 Mouse
Unigene: 660998 Human
Unigene: 735847 Human
Unigene: 335020 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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