Rabbit Anti-ZWINT/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-ZWINT/FITC Conjugated antibody

HZwint1; KNTC 2 AP; KNTC2AP; MGC 117174; MGC117174; ZW10 interacting protein 1; ZW10 interactor; ZWINT 1; ZWINT1; ZWINT-1; ZWINT_HUMAN.

Cat:

SL7852R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from huamn ZWINT

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

31 kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
ZWINT is a component of the MIS12 complex, which is required for kinetochore function and spindle checkpoint activity. ZWINT interacts with ZW10 and targets it to the kinetochore at prometaphase. ZWINT is detectable on the kinetochore till late anaphase. Inhibition of ZWINT expression results in chromosome missegregation, spindle checkpoint failure and, ultimately, cell death upon cytokinesis.

Function:
Part of the MIS12 complex, which is required forkinetochore formation and spindle checkpoint activity. Required totarget ZW10 to the kinetochore at prometaphase.

Subunit:
Interacts with ZW10 and MIS12. Interacts with the NDC80subunit of the NDC80 complex specifically during mitosis. Alsointeracts with CASC5, CETN3, DSN1 and PMF1.

Subcellular Location:
Nucleus. Chromosome, centromere,kinetochore. Note=Localizes to kinetochores from late prophase toanaphase.

Database links:
UniProtKB/Swiss-Prot: O95229.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall