background:
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules.
Subunit:
Component of the SKA1 complex, composed of SKA1, SKA2 and SKA3. Forms a heterodimer with SKA2; the heterodimer interacting with SKA3. The core SKA1 complex is composed of 2 SKA1-SKA2 heterodimers, each heterodimer interacting with a molecule of the SKA3 homodimer. The core SKA1 complex associates with microtubules and forms oligomeric assemblies. Interacts directly with microtubules, SKA2 and SKA3.
Subcellular Location:
Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
Similarity:
Belongs to the SKA1 family.
Database links:
Entrez Gene: 220134 Human
Entrez Gene: 66468 Mouse
Entrez Gene: 291441 Rat
SwissProt: Q96BD8 Human
SwissProt: Q9CPV1 Mouse
SwissProt: B0BN28 Rat
Unigene: 134726 Human
Unigene: 283406 Mouse
Unigene: 106906 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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