background:
Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.
Function:
Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.
Subunit:
Subunit of dynactin, a multiprotein complex associated with dynein. Interacts with BICD2 and CEP135.
Subcellular Location:
Cytoplasm, cytoskeleton, centrosome. Membrane; Peripheral membrane protein.
Similarity:
Belongs to the dynactin subunit 2 family.
Database links:
UniProtKB/Swiss-Prot: Q13561.4
Entrez Gene: 10540 Human
Entrez Gene: 69654 Mouse
Omim: 607376 Human
SwissProt: Q13561 Human
SwissProt: Q99KJ8 Mouse
Unigene: 289123 Human
Unigene: 167537 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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