background:
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
Function:
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
Subunit:
Interacts with BUB1 and BUBR1. The BUB1/BUB3 complex interacts with MAD1L1.
Subcellular Location:
Nucleus. Chromosome, centromere, kinetochore (By similarity).
Post-translational modifications:
Poly-ADP-ribosylated by PARP1 (By similarity).
Similarity:
Belongs to the WD repeat BUB3 family. Contains 5 WD repeats.
Database links:
Entrez Gene: 539594 Cow
Entrez Gene: 9184 Human
Entrez Gene: 12237 Mouse
Entrez Gene: 100172494 Orangutan
Entrez Gene: 361662 Rat
Omim: 603719 Human
SwissProt: Q1JQB2 Cow
SwissProt: O43684 Human
SwissProt: Q9WVA3 Mouse
SwissProt: Q5RB58 Orangutan
Unigene: 418533 Human
Unigene: 441749 Mouse
Unigene: 927 Mouse
Unigene: 6897 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
