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Rabbit Anti-APC6/FITC Conjugated antibody
background:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Function:
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Subunit:
The APC/C is composed of at least 12 subunits. Interacts with PPP5C and CDC20.
Subcellular Location:
Cytoplasm; cytoskeleton; centrosome. Cytoplasm; cytoskeleton; spindle. Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.
Post-translational modifications:
Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis.
Similarity:
Belongs to the APC6/CDC16 family.
Contains 7 TPR repeats.
Database links:
Entrez Gene: 8881 Human
Entrez Gene: 69957 Mouse
Omim: 603461 Human
SwissProt: Q13042 Human
SwissProt: Q8R349 Mouse
Unigene: 374127 Human
Unigene: 182412 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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