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Rabbit Anti-ALOXE3/FITC Conjugated antibody
background:
Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known.
Tissue specificity:Predominantly expressed in skin.
Involvement in diseaseDefects in ALOXE3 are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE). NCIE is a non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume.
Tissue Specificity:
Predominantly expressed in skin.
Similarity:
Belongs to the lipoxygenase family. Contains 1 lipoxygenase domain. Contains 1 PLAT domain.
Database links:
Entrez Gene: 59344 Human
Entrez Gene: 4761 Mouse
Entrez Gene: 287424 Rat
Omim: 607206 Human
SwissProt: Q9BYJ1 Human
SwissProt: Q9WV07 Mouse
Unigene: 232770 Human
Unigene: 41989 Mouse
Unigene: 8716 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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