background:
This gene was identified on the basis of its stimulationby c-Myc protein. The latter is a transcription factor thatparticipates in the regulation of cell proliferation,differentiation, and apoptosis. The exact function of this gene isnot known but studies in rat suggest a role in cellularproliferation and c-Myc-mediated transformation. Two alternativetranscripts encoding different proteins have been described.[provided by RefSeq, Jul 2008].
Function:
Catalyzes the cleavage of the N-glycosidic bond ofdeoxyribonucleoside 5'-monophosphates to yield deoxyribose5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside5'-monophosphates containing purine bases are preferred to thosecontaining pyrimidine bases (By similarity).
Subunit:
Monomer and homodimer (By similarity).
Subcellular Location:
Nucleus (By similarity). Cytoplasm.
Tissue Specificity:
Expressed at low levels in brain, colon, lung,peripheral blood leukocytes, placenta, small intestine, and thymus.Expressed at high levels in heart, kidney, liver, skeletal muscleand spleen. Overexpressed in a significant proportion of breastcancers.
Similarity:
Belongs to the deoxyribonucleoside 5'-monophosphateN-glycosidase family
Database links:
UniProtKB/Swiss-Prot: O43598.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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