background:
Rab GTPase-activating protein 1 is a 1,069 amino acid cytoplasmic protein containing one PID domain and one Rab-GAP TBC domain. Rab GAP1 acts as a GTPase-activating protein of Rab 6A in the Rab 6A-mediated pathway, which is involved in the metaphase-anaphase transition. Expressed as four alternatively spliced variants, Rab GAP1 may also be involved in the microtubule nucleation by centrosome and in Golgi dynamics during the cell cycle. Rab GAP1 is encoded by a gene located on human chromosome 9, which consists of about 145 million bases, 4% of the human genome and encodes nearly 900 genes.
Function:
May act as a GTPase-activating protein of RAB6A. Mayplay a role in microtubule nucleation by centrosome. Mayparticipate in a RAB6A-mediated pathway involved in themetaphase-anaphase transition.
Subunit:
Interacts with RAB6A and tubulin gamma.
Subcellular Location:
Cytoplasm, cytosol. Cytoplasm, cytoskeleton,centrosome. Note=Predominantly cytosolic but also associated withthe centrosome.
Similarity:
Contains 1 PID domain.
Contains 1 Rab-GAP TBC domain.
Database links:
Entrez Gene: 519260 Cow
Entrez Gene: 23637 Human
Entrez Gene: 227800 Mouse
Entrez Gene: 311911 Rat
SwissProt: Q9Y3P9 Human
SwissProt: A2AWA9 Mouse
Unigene: 271341 Human
Unigene: 383192 Mouse
Unigene: 14944 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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