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Rabbit Anti-CDC45L/FITC Conjugated antibody
background:
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Function:
Required for initiation of chromosomal DNA replication.<
Subunit:
Associated with ORC2.
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Widely expressed, highest levels are found in adult testis and thymus and in fetal liver.
Similarity:
Belongs to the CDC45 family.
Database links:
Entrez Gene: 8318 Human
Entrez Gene: 12544 Mouse
Entrez Gene: 287961 Rat
Omim:
603465 Human
SwissProt:
O75419 Human
SwissProt:
Q9Z1X9 Mouse
Unigene: 474217 Human
Unigene: 1248 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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