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Rabbit Anti-CDC123/FITC Conjugated antibody
background:
Required for S phase entry of the cell cycle.The eukaryotic cell division cycle consists of a number of gene-controlled sequences that involve cyclin dependent kinases (Cdks) and cell division control (Cdc) proteins. Cdc123 (Cell division cycle protein 123), also known as D123, is a 336 amino acid cytoplasmic protein that is involved in cell cycle control. Widely expressed with high expression in thymus, spleen, ovary, testis, small intestine and leukocytes, Cdc123 functions to destabilize Chfr (checkpoint with forkhead and ring finger domain) proteins which, when accumulated, block the G to S phase transition. Cdc123 prevents the Chfr proteins from collecting in the cell, thereby allowing the cell to enter the S phase. Due to its role in cell cycle control, Cdc123 is thought to be a basal marker for luminal breast cancers.
Function:
Required for S phase entry of the cell cycle
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes with the highest expression in testis.
Similarity:
Belongs to the CDC123 family.
Database links:
Entrez Gene: 8872 Human
Entrez Gene: 98828 Mouse
Entrez Gene: 116656 Rat
SwissProt: O75794 Human
SwissProt: Q8CII2 Mouse
SwissProt: Q62834 Rat
Unigene: 412842 Human
Unigene: 181490 Mouse
Unigene: 11096 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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