background:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Subunit:
Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG.
Subcellular Location:
CNucleus. Cytoplasm. Chromosome.
Tissue Specificity:
Widely expressed at low level. Expressed in proliferating cells.
Post-translational modifications:
Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity).
Similarity:
Belongs to the CND2 (condensin subunit 2) family.
Database links:
UniProtKB/Swiss-Prot: Q3003.3
Entrez Gene: 23397 Human
Entrez Gene: 215387 Mouse
Omim: 602332 Human
SwissProt: Q3003 Human
SwissProt: Q8C156 Mouse
Unigene: 308045 Human
Unigene: 29786 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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