background:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
Tissue specificity:Detected in spleen, thymus, testis, ovary, small intestine and colon, with highest levels of expression in testis and ovary.
Function:
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
Subunit:
Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Binds UCHL5.
Subcellular Location:
Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules.
Tissue Specificity:
Detected in spleen, thymus, testis, ovary, small intestine and colon, with highest levels of expression in testis and ovary.
Similarity:
Belongs to the HAUS7 family.
Database links:
UniProtKB/Swiss-Prot: Q99871.3
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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