Rabbit Anti-NEDD1/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-NEDD1/FITC Conjugated antibody

GCP WD; Neural precursor cell expressed, developmentally down regulated gene 1; TUBGCP7; FLJ35902; NEDD1_HUMAN.

Cat:

SL7813R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human NEDD1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

72kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
May play an important role during the embryonic development and differentiation of the central nervous system. Human NEDD1 localises to the centrosome and mitotic spindle. It binds to the components of the gamma-tubulin ring complex and target this complex to the centrosome and spindle.

Function:
Required for mitosis progression. Promotes thenucleation of microtubules from the spindle.

Subunit:
Interacts with FAM29A and gamma-tubulin.

Subcellular Location:
Cytoplasm, cytoskeleton, centrosome.

Post-translational modifications:
During mitosis, prior phosphorylation on Thr-550 by CDK1promotes subsequent phosphorylation by PLK1 on Thr-382, Ser-397,Ser-426 and Ser-637. Phosphorylated NEDD1 can interact withgamma-tubulin for targeting the gamma-tubulin ring complex (gTuRC)to the centrosome, an important step for spindle formation.

Similarity:
Contains 8 WD repeats.

Database links:
UniProtKB/Swiss-Prot: Q8NHV4.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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