background:
Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation.
Tissue specificity:Expressed most abundantly in ovary and, at lower levels, in prostate, spleen and testis. Weak expression, if any, in thymus, small intestine, colon and peripheral blood leukocytes.
Function:
Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation.
Subunit:
Interacts with AR, but not with ESR1, NR3C1, PGR, THRB nor VDR.
Subcellular Location:
Nucleus speckle. Cytoplasm.
Tissue Specificity:
Expressed most abundantly in ovary and, at lower levels, in prostate, spleen and testis. Weak expression, if any, in thymus, small intestine, colon and peripheral blood leukocytes.
Similarity:
Contains 1 SP-RING-type zinc finger.
Database links:
UniProtKB/Swiss-Prot: Q9ULJ6.3
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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