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Rabbit Anti-ERCC6L/FITC Conjugated antibody
background:
ERCC6L belongs to the SNF2 ATPase family and acts as an essential component of the spindle assembly checkpoint. It contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. It acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L may also play a role in the teratogenic action of alcohol.
Function:
DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase.
Subunit:
Interacts with PLK1, which phosphorylates it. Both proteins are mutually dependent on each other for correct subcellular localization.
Subcellular Location:
Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset.
Post-translational modifications:
Phosphorylation by PLK1 prevents the association with chromosome arms and restricts its localization to the kinetochore-centromere region.
Similarity:
Belongs to the SNF2/RAD54 helicase family.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase SLCterminal domain.
Contains 2 TPR repeats.
Database links:
Entrez Gene: 54821 Human
Omim: 300687 Human
SwissProt: Q2NKX8 Human
Unigene: 47558 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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