Rabbit Anti-BS69/FITC Conjugated antibody

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Adenovirus 5 E1A binding protein; Bone morphogenetic protein receptor associated molecule 1; BRAM1; BS69 variant 1; BS69 variant 2; BS69 variant 3; BS69 variant 4; Zinc finger MYND domain containing 11; ZMYND11.

Cat:

SL7697R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human Adenovirus 5 E1A binding protein (535-584aa)

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

71kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Function:
Corepressor of transcription (Probable). May be involved in chromatin remodeling through association with several remodeling factors.

Subunit:
Interacts (via MYND-type zinc finger) with NCOR1. Interacts (via MYND-type zinc finger) with human adenovirus early E1A protein (via PXLXP motif); this interaction inhibits E1A mediated transactivation. Interacts (via MYND-type zinc finger) with Epstein-Barr virus EBNA2 protein (via PXLXP motif). Interacts (via MYND-type zinc finger) with EZH2. Interacts with E2F6.

Subcellular Location:
Nucleus. Chromosome. Note=Associates with chromatin and mitotic chromosomes.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Ubiquitinated, leading to proteasomal degradation.

Similarity:
Contains 1 bromo domain.
Contains 1 MYND-type zinc finger.
Contains 1 PHD-type zinc finger.
Contains 1 PWWP domain.

Database links:

Entrez Gene: 10771 Human

Entrez Gene: 66505 Mouse

Entrez Gene: 291259 Rat

GenBank: NP_006615 Human

GenBank: NP_997644 Human

Omim: 608668 Human

SwissProt: Q15326 Human

SwissProt: Q8R5C8 Mouse

Unigene: 292265 Human

Unigene: 397307 Mouse

Unigene: 38301 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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