background:
The P2X receptor family is comprised of ligand-gated ion channels that allow for the increased permeability of calcium into the cell in response to extracellular ATP. The seven P2X receptors, P2X1-P2X7, form either homomeric or heteromeric channels or both. They are characterized by intracellular amino- and carboxy-termini. P2X receptors are expressed in a wide variety of tissues, including neurons, prostate, bladder, pancreas, colon, testis and ovary. The major function of the P2X receptors is to mediate synaptic transmissions between neurons and to other tissues via the binding of extracellular ATP, which acts as a neurotransmitter. The P2X receptors may be involved in the onset of necrosis or apoptosis after prolonged exposure to high concentrations of extracellular ATP.
Function:
Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.
Subunit:
Functional P2XRs are organized as homomeric and heteromeric trimers.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Similarity:
Belongs to the P2X receptor family.
Database links:
Entrez Gene: 338036 Cow
Entrez Gene: 448783 Dog
Entrez Gene: 5025 Human
Entrez Gene: 18438 Mouse
Entrez Gene: 100458831 Orangutan
Entrez Gene: 29659 Rat
Omim: 600846 Human
SwissProt: Q5E9U1 Cow
SwissProt: Q99571 Human
SwissProt: Q9JJX6 Mouse
SwissProt: P51577 Rat
Unigene: 321709 Human
Unigene: 290884 Mouse
Unigene: 463383 Mouse
Unigene: 7176 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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