background:
TNF receptor associated factor 7 (TRAF7) is an E3 ubiquitin ligase capable of auto ubiquination, following phosphorylation by MAP3K3. TRAF7 potentiates MEKK3 mediated activation of the NFkappaB, JUN/AP1 and DDIT3 transcriptional regulators. TRAF7 induces apoptosis when over expressed.
Function:
E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.
Subunit:
Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme.
Subcellular Location:
Colocalizes with MAP3K3 to vesicle like structures throughout the cytoplasm.
Tissue Specificity:
Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.
Post-translational modifications:
Phosphorylated by MAP3K3.
Ubiquitinates itself upon phosphorylation.
Similarity:
Belongs to the WD repeat TRAF7 family.
Contains 1 RING-type zinc finger.
Contains 1 TRAF-type zinc finger.
Contains 7 WD repeats.
Database links:
Entrez Gene: 84231 Human
Entrez Gene: 224619 Mouse
Entrez Gene: 72491 Rat
Omim: 606692 Human
SwissProt: Q6Q0C0 Human
SwissProt: Q922B6 Mouse
Unigene: 713632 Human
Unigene: 275150 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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