background:
Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo.
Function:
Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo.
Subunit:
Isoform 1 and isoform 2 interact with TCEA1. Interacts with ELL and ELL2.
Subcellular Location:
Nucleus speckle.
Tissue Specificity:
Expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, prostate, testis, small intestine, colon, adrenal, bone marrow, lymph node, spinal gland, stomach, thyroid, trachea, thymus, liver and leukocytes.
Similarity:
Belongs to the EAF family.
Database links:
Entrez Gene: 55168 Human
Entrez Gene: 106389 Mouse
Entrez Gene: 266787 Rat
Omim: 607659 Human
SwissProt: Q96CJ1 Human
SwissProt: Q91ZD6 Mouse
SwissProt: Q811X5 Rat
Unigene: 477325 Human
Unigene: 46478 Mouse
Unigene: 20681 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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