Rabbit Anti-DNase gamma/FITC Conjugated antibody

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Deoxyribonuclease gamma; Deoxyribonuclease I like 3; Deoxyribonuclease I like III; Deoxyribonuclease I-like 3; DHP2; DNAS1L3; DNase gamma; DNase I homolog protein 2; DNase I homolog protein DHP2; DNase I like 3; DNase I-like 3; DNASE1L3; DNSL3_HUMAN; Live

Cat:

SL7653R-FITC

Species Reactivity：

Mouse,Rat,(predicted: Human,Pig,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human DNase gamma

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

36kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units.

Function:
Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units.

Subcellular Location:
Nucleus.

Tissue Specificity:
Liver and spleen.

DISEASE:
Defects in DNASE1L3 are the cause of systemic lupus erythematosus type 16 (SLEB16) [MIM:614420]. A rare autosomal recessive form of systemic lupus erythematosus with childhood onset, characterized by high frequency of anti-neutrophil cytoplasmic antibodies and lupus nephritis. Systemic lupus erythematosus is a chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

Similarity:
Belongs to the DNase I family.

Database links:

Entrez Gene: 1776 Human

Entrez Gene: 13421 Mouse

Entrez Gene: 116687 Rat

Omim: 602244 Human

SwissProt: Q1729 Human

SwissProt: O55070 Mouse

SwissProt: O89107 Rat

Unigene: 476453 Human

Unigene: 272258 Mouse

Unigene: 29996 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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