Rabbit Anti-ARTS1/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-ARTS1/FITC Conjugated antibody

Endoplasmic reticulum aminopeptidase 1; A LAP; A-LAP; Adipocyte derived leucine aminopeptidase; Adipocyte-derived leucine aminopeptidase; ALAP; Aminopeptidase PILS; APPILS; ARTS 1; ARTS-1; Arts1; Endoplasmic reticulum aminopeptidase 1; ERAAP; ERAP 1; Erap

Cat:

SL7643R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human ARTS1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

107kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic SLCterminus, while it has weak activity toward peptides with charged SLCterminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.

Function:
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic SLCterminus, while it has weak activity toward peptides with charged SLCterminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.

Subunit:
Monomer. May also exist as a heterodimer; with ERAP2. Interacts with RBMX.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type II membrane protein (Probable).

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
N-glycosylated.

Similarity:
Belongs to the peptidase M1 family.

Database links:

Entrez Gene: 51752 Human

Entrez Gene: 80898 Mouse

Entrez Gene: 80897 Rat

Omim: 606832 Human

SwissProt: Q9NZ08 Human

SwissProt: Q9EQH2 Mouse

SwissProt: Q9JJ22 Rat

Unigene: 716426 Human

Unigene: 83526 Mouse

Unigene: 22516 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall