Rabbit Anti-XKR1/FITC Conjugated antibody

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XK; Kell complex 37 kDa component; Membrane transport protein XK; XK related protein 1; XKR1; XRG1.

Cat:

SL7128R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,)

Immunogen：

KLH conjugated synthetic peptide derived from human XKR1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

49kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
XK is the Kell blood group 'precursor substance'. This protein has structural characteristics of prokaryotic and eukaryotic membrane transport proteins. The Kell blood group is constituted by two covalently linked antigens at the surface of red blood cells, Kell and KX. Whereas Kell is a metalloprotease with demonstrated in vitro enzymatic activity, the role of KX thereon, and/or alone, remains unknown, although its absence is linked to the McLeod syndrome, a neuroacanthocytosis. KX appears to be required for proper synthesis or presentation of the Kell antigens on the red blood cell surface.

Function:
May be involved in sodium-dependent transport of neutral amino acids or oligopeptides

Subunit:
Heterodimer with Kell; disulfide-linked.

Subcellular Location:
Membrane; Multi-pass membrane protein (Potential).

Tissue Specificity:
High levels in skeletal muscle, heart, brain,

DISEASE:
Defects in XK are the cause of McLeod syndrome (MLS) [MIM:300842]. It is an X-linked multisystem disorder characterized by late onset abnormalities in the neuromuscular and hematopoietic systems.

Similarity:
Belongs to the XK family.

Database links:

Entrez Gene: 7504 Human

Entrez Gene: 22439 Mouse

Entrez Gene: 497078 Rat

Omim: 314850 Human

SwissProt: P51811 Human

SwissProt: Q9QXY7 Mouse

SwissProt: Q5GH61 Rat

Unigene: 78919 Human

Unigene: 56468 Mouse

Unigene: 211877 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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