background:
In humans, mutations of the gene encoding the homeobox transcription factor Nkx2.5 result in electrical conduction defects and morphological abnormalities of the heart (Dupays et al., 2005). In the heart, Nkx2.5 is expressed in both the myocardium and the endocardium. Differentiation of embryonic stem cells to Nkx2.5-positive cardiomyocytes is facilitated by Wnt11.
Subcellular Location:
Nuclear
Database links:
Clone ID: 396073 Chicken
Entrez Gene: 1482 Human
Entrez Gene: 3691 Mouse
Entrez Gene: 114109 Rat
Omim: 600584 Human
SwissProt: Q90788 Chicken
SwissProt: P52952 Human
SwissProt: P42582 Mouse
SwissProt: O35767 Rat
Unigene: 638 Chicken
Unigene: 54473 Human
Unigene: 41974 Mouse
Unigene: 6179 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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