background:
STK3 is a stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation.
Subunit:
Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation. Interacts with and stabilizes SAV1. Interacts with RAF1, which prevents dimerization and phosphorylation. Interacts with RASSF1. Interacts (via SARAH domain) with isoform 1 of NEK2. Interacts with ESR1 only in the presence of SAV1. Interacts with PKB/AKT1. Forms a tripartite complex with MOBKL1B and STK38. Interacts with RASSF2 (via SARAH domain).
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Expressed at high levels in adult kidney, skeletal and placenta tissues and at very low levels in adult heart, lung and brain tissues.
Similarity:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Contains 1 protein kinase domain.
Contains 1 SARAH domain.
Database links:
Entrez Gene: 8428 Human
Entrez Gene: 223255 Mouse
Entrez Gene: 361092 Rat
Omim: 604984 Human
SwissProt: Q9Y6E0 Human
SwissProt: Q99KH8 Mouse
SwissProt: B0LT89 Rat
Unigene: 508514 Human
Unigene: 390756 Mouse
Unigene: 442081 Mouse
Unigene: 472866 Mouse
Unigene: 105397 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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