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Rabbit Anti-ERN2/FITC Conjugated antibody
background:
ERN2, endoplasmic reticulum to nucleus signaling 2, induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. It is pro-apoptotic and appears to play no role in the unfolded-protein response, unlike closely related proteins.
Function:
Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.
Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Post-translational modifications:
Autophosphorylated.
Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Contains 1 KEN domain.
Contains 1 protein kinase domain.
Database links:
Entrez Gene: 10595 Human
Entrez Gene: 26918 Mouse
Omim: 604034 Human
SwissProt: O7592 Human
SwissProt: Q9EQY0 Mouse
Unigene: 133982 Human
Unigene: 20452 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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