Rabbit Anti-RING finger protein 189/FITC Conjugated antibody

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CARP-2; CARP2; Caspase regulator CARP2; Caspases 8 and 10 associated RING finger protein 2; Caspases-8 and -10-associated RING finger protein 2; E3 ubiquitin protein ligase rififylin; E3 ubiquitin-protein ligase rififylin; Fring; FYVE RING finger protein

Cat:

SL6872R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human RING finger protein 189

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

40kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.

Subunit:
Binds CASP8 and CASP10.

Subcellular Location:
Cytoplasm. Membrane; Peripheral membrane protein.

Tissue Specificity:
Ubiquitous. Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.

Post-translational modifications:
Rapidly degraded after stimulation with TNFSF10, probably by caspases.
Auto-ubiquitinated (in vitro).
Palmitoylated.

Similarity:
Contains 1 FYVE-type zinc finger.
Contains 1 RING-type zinc finger.
Contains 2 SAP domains.

Database links:

Entrez Gene: 530263 Cow

Entrez Gene: 117584 Human

Entrez Gene: 67338 Mouse

Entrez Gene: 282844 Rat

Omim: 609735 Human

SwissProt: Q8WZ73 Human

SwissProt: Q6ZQM0 Mouse

SwissProt: Q8CIN9 Rat

Unigene: 1736 Human

Unigene: 341608 Mouse

Unigene: 159718 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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