Rabbit Anti-Nucleolar protein 3/FITC Conjugated antibody

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Apoptosis repressor with CARD; ARC; Muscle enriched cytoplasmic protein; MYC; Myp; NOP; Nop30; Nucleolar protein 3 (apoptosis repressor with CARD domain); Nucleolar protein 3; Nucleolar protein of 30 kDa; NOL3_MOUSE .

Cat:

SL7080R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,Dog,Cow,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from mouse Nucleolar protein 3/Apoptosis repressor with CARD

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

25kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD)bcontaining molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, BCL10, Apaf 1, caspase 9 and caspase 2. Apoptosis repressor with CARD is a CARD domain containing protein that interacts with caspase 2 and 8 to inhibit enzymatic activity of caspase 8. Apoptosis repressor with CARD suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR 1, and DR3. The mRNA of Apoptosis repressor with CARD is primarily expressed in skeletal muscle and cardiac tissue. The nuclear isoform (1/Nop30) may be involved in RNA splicing and the cytoplasmic isoform (2/Myp) may inhibit apoptosis.

Function:
May be involved in RNA splicing (By similarity).

Subunit:
Interacts with SFRS9/SRp30c, NPM1, CASP2, CASP8 and TFPT (By similarity).

Subcellular Location:
Cytoplasm and Nucleus > nucleolus.

Similarity:
Contains 1 CARD domain.

Database links:

Entrez Gene: 8996 Human

Entrez Gene: 78688 Mouse

Entrez Gene: 85383 Rat

Omim: 605235 Human

SwissProt: O60936 Human

SwissProt: Q9D1X0 Mouse

SwissProt: Q62881 Rat

Unigene: 513667 Human

Unigene: 204876 Mouse

Unigene: 475715 Mouse

Unigene: 86956 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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