background:
SLC25A6 (solute carrier family 25, member A6) participates in the exchange of ADP and ATP across the mitochondrial inner membrane. It may be involved in the formation of the permeability transition pore complex (PTPC), a multiprotein complex built up at the contact site between the inner and the outer mitochondrial membranes. Opening of the PTPC causes massive swelling of mitochondria, rupture of the outer membrane and release of intermembrane components that induce apoptosis.
Function:
Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Subunit:
Found in a complex with ARL2, ARL2BP and SLC25A6. Homodimer. Interacts with influenza A virus PB1-F2 protein and HISLV1 Vpr.
Subcellular Location:
Mitochondrion inner membrane; Multi-pass membrane protein.
Similarity:
Belongs to the mitochondrial carrier family.
Contains 3 Solcar repeats.
Database links:
Entrez Gene: 293 Human
Entrez Gene: 374072 Chicken
Entrez Gene: 28496 Cow
Entrez Gene: 67582 Mouse
Entrez Gene: 498885 Rat
Entrez Gene: 566370 Zebrafish
Omim: 300151 Human
Omim: 403000 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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