background:
The human TNIP2 (also known as ABIN-2), which is related to proteins ABIN-1 and ABIN-3, was originally identified as an A20-associating cytosolic protein that block nuclear factor kappaB (NF-kB) activation. NF-kB plays a central role in the regulation of genes implicated in immune responses, inflammatory processes, and apoptotic cell death and the zinc finger protein A20 is a potent inhibitor of NF-kB activity with a key role in limiting the extent and duration of inflammatory activation. It was also reported that ABIN-2 has the potential to enter the nucleus and plays a role in mediating transcriptional activation in both yeast and mammalian cells.
Function:
Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
Subunit:
nteracts with STK11/LKB1, TNFAIP3, IKBKG, NFKB1, MAP3K8, TEK, RIPK1, CHUK, IKBKB and SMARCD1. Interacts with polyubiquitin
Tissue Specificity:
Ubiquitously expressed in all tissues examined.
Post-translational modifications:
In vitro phosphorylated by CHUK (By similarity).
Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination probably leading to constitutive proteasomal degradation which can be impaired by IKK-A/CHUK or IKBKB probbaly involving deubiquitination (By similarity).
Database links:
Entrez Gene: 79155 Human
Entrez Gene: 231130 Mouse
Omim: 610669 Human
SwissProt: Q8NFZ5 Human
SwissProt: Q99JG7 Mouse
Unigene: 726088 Human
Unigene: 28615 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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