background:
Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase /c-Jun N-terminal kinase (SAPK/JNK)
Function:
Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity).
Subunit:
Monomer.
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Ubiquitous. Highest expression seen in heart, placenta, lung, liver, kidney and pancreas.
Post-translational modifications:
Myristoylation regulates subcellular location, and is necessary for activation of JNK.
Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Contains 1 tyrosine-protein phosphatase domain.
Database links:
Entrez Gene: 56940 Human
Entrez Gene: 105352 Mouse
Entrez Gene: 361242 Rat
SwissProt: Q9NRW4 Human
SwissProt: Q99N11 Mouse
Unigene: 29106 Human
Unigene: 289646 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|