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Rabbit Anti-MSR1/FITC Conjugated antibody
background:
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
Function:
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize actetylated LDL.
Subunit:
Homotrimer.
Subcellular Location:
Membrane; Single-pass type II membrane protein.
Tissue Specificity:
Isoform I, isoform II and isoform III are expressed in monocyte-derived macrophages.
DISEASE:
Defects in MSR1 may be a cause of prostate cancer (PC)[MIM:171367]. A malignancy originating in tissues of the prostate.Most prostate cancers are adenocarcinomas that develop in the aciniof the prostatic ducts. Other rare histopathologic types ofprostate cancer that occur in approximately 5% of patients includesmall cell carcinoma, mucinous carcinoma, prostatic ductalcarcinoma, transitional cell carcinoma, squamous cell carcinoma,basal cell carcinoma, adenoid cystic carcinoma (basaloid),signet-ring cell carcinoma and neuroendocrine carcinoma. Note=MSR1variants may play a role in susceptibility to prostate cancer. MSR1variants have been found in individuals with prostate cancer andco-segregate with the disease in some families.
Defects in MSR1 may be a cause of Barrett esophagus (BE)[MIM:614266]. A condition characterized by a metaplastic change inwhich normal esophageal squamous epithelium is replaced by acolumnar and intestinal-type epithelium. Patients with Barrettesophagus have an increased risk of esophageal adenocarcinoma. Themain cause of Barrett esophagus is gastroesophageal reflux. Theretrograde movement of acid and bile salts from the stomach intothe esophagus causes prolonged injury to the esophageal epitheliumand induces chronic esophagitis, which in turn is believed totrigger the pathologic changes. Note=Genetic variants in MSR1 havebeen found in individuals with Barrett esophagus and are thought tocontribute to disease susceptibility.
Similarity:
Contains 1 collagen-like domain.
Contains 1 SRCR domain.
Database links:
Entrez Gene: 281311 Cow
Entrez Gene: 4481 Human
Entrez Gene: 498638 Rat
Omim: 153622 Human
SwissProt: P21758 Cow
SwissProt: P21757 Human
Unigene: 147635 Human
Unigene: 231068 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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