background:
Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure.
Tissue specificity:
Ubiquitous with higher expression in heart, brain and skeletal muscle.
Function:
Plays a role of stimulator of transcription factors andnuclear receptors activities. Activates transcritional activity ofestrogen receptor alpha, nuclear respiratory factor 1 (NRF1) andglucocorticoid receptor in the presence of glucocorticoids. Mayplay a role in constitutive non-adrenergic-mediated mitochondrialbiogenesis as suggested by increased basal oxygen consumption andmitochondrial number when overexpressed. May be involved in fatoxidation and non-oxidative glucose metabolism and in theregulation of energy expenditure.
Subunit:
Interacts with hepatocyte nuclear factor 4-alpha/HNF4A,Sterol regulatory binding transcription factor 1/SRESF1,PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cellfactor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRGand alpha/ESRRA. Interacts with PRDM16 (By similarity). Interactswith estrogen receptor alpha/ESR1.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitous with higher expression in heart,brain and skeletal muscle.
Similarity:
Contains 1 RRM (RNA recognition motif) domain.
Database links:
UniProtKB/Swiss-Prot: Q86YN6.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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