background:
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]
Function:
Binds to one of the cis-acting domain of the insulin gene enhancer.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain.
Similarity:
Contains 1 homeobox DNA-binding domain.
Contains 2 LIM zinc-binding domains.
Database links:
Entrez Gene: 396383 Chicken
Entrez Gene: 3670 Human
Entrez Gene: 16392 Mouse
Entrez Gene: 64444 Rat
Omim: 600366 Human
SwissProt: P50211 Chicken
SwissProt: P61371 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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