Rabbit Anti-Involucrin/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-Involucrin/FITC Conjugated antibody

INVO_HUMAN; involucrin; ivl.

Cat:

SL1236R-FITC

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human Involucrin

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

64kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008].

Function:
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.

Subunit:
Directly or indirectly cross-linked to cornifelin (CNFN).

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Keratinocytes of epidermis and other stratified squamous epithelia.

Post-translational modifications:
Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide.

Similarity:
Belongs to the involucrin family.

Database links:

Entrez Gene: 3713 Human

Entrez Gene: 16447 Mouse

Entrez Gene: 60583 Rat

Omim: 14772 Human

SwissProt: P07476 Human

SwissProt: P48997 Mouse

SwissProt: P48998 Rat

Unigene: 516439 Human

Unigene: 207365 Mouse

Unigene: 142591 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

套膜蛋白又称内披蛋白或囊包蛋白，与毛透明蛋白共同构成角质细胞包膜支架的蛋白质。在角质细胞分化时，首先出现在表皮棘层的上层细胞中的标志性蛋白质，该蛋白在角质细胞和其他复层扁平上皮合成的蛋白。最初存在于细胞质中，然后通过转谷氨酰胺酶的作用，转变为交联的膜蛋白。

Product Feedback Wall