Rabbit Anti-stabilin1/FITC Conjugated antibody

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CLEVER 1; Common lymphatic endothelial and vascular endothelial receptor 1; Fasciclin EGF like laminin type EGF like and link domain containing scavenger receptor 1; fasciclin egf-like; FEEL 1; FELE 1; FEX1; KIAA0246; MS 1 antigen; STAB1; STAB-1; STAB 1;

Cat:

SL7510R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human stabilin1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

273kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Stabilin-1 is a large transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a SLCtype lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes.

Function:
Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.

Subunit:
Interacts with CHID1.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells.

Similarity:
Contains 16 EGF-like domains.
Contains 7 FAS1 domains.
Contains 2 laminin EGF-like domains.
Contains 1 Link domain.

Database links:

Entrez Gene: 23166 Human

Omim: 608560 Human

SwissProt: Q9NY15 Human

Unigene: 301989 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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