Rabbit Anti-SMOC2/FITC Conjugated antibody

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Secreted modular calcium binding protein 2; SMAP 2; SMAP2; SMOC 2; Smooth muscle associated protein 2; SPARC related modular calcium binding 2; dJ421D16.1; MST117; MSTP117; bA270C4A.1; bA37D8.1; dJ421D16.1 (novel thyroglobulin type 1 repeat containing pro

Cat:

SL7506R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,Dog,Pig,Cow,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human SMOC2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

47kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
SMOC 2 (Secreted modular calcium binding protein 2) is a secreted modular protein containing an EF hand calcium binding domain homologous to that in BM40. It consists of two thyroglobulin like domains, a follistatin like domain and a novel domain found only in the homologous SMOC 1. SMOC 1 and 2 form a separate group within the BM40 family. SMOC 2 is a glycoprotein with a calcium dependent conformation. SMOC 2 contains 2 EF hand calcium binding domains, 1 Kazal like domain and 2 thyroglobulin type I domains.

Function:
Promotes matrix assembly and cell adhesiveness. Can stimulate endothelial cell proliferation, migration, as well as angiogenesis.

Subunit:
Binds various proteins from the extracellular matrix.

Subcellular Location:
Secreted, extracellular space, extracellular matrix, basement membrane.

DISEASE:
Defects in SMOC2 are the cause of dentin dysplasia typ1 (DTDP1) [MIM:125400]. A dental defect in which both primary and secondary dentitions are affected. The clinical crowns of both permanent and deciduous teeth are of normal shape, form and color in most cases, although they may be slightly opalescent and blue or brown. Teeth may be very mobile and exfoliate spontaneously because of inadequate root formation. On radiographs, the roots are short and may be more pointed than normal. Pulp chambers are usually absent except for a chevron-shaped remnant in the crown. Root canals are usually absent.

Similarity:
Contains 2 EF-hand domains.
Contains 1 Kazal-like domain.
Contains 2 thyroglobulin type-1 domains.

Database links:

Entrez Gene: 12894 Human

Entrez Gene: 12874 Mouse

Omim: 607223 Human

SwissProt: Q9H3U7 Human

SwissProt: Q8CD91 Mouse

Unigene: 481440 Human

Unigene: 30162 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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