Home > Product > Antibody > Rabbit Anti-DLK1/FITC Conjugated antibody
Adipocyte differentiation inhibitor protein; Brevideltin; Delta like 1 homolog; Delta like homolog; Delta like protein; Delta1; DLK 1; DLK; DLK-1; Dlk1; DLK1_HUMAN; FA 1; FA1; Fetal antigen 1; pG2; Preadipocyte factor 1; Pref 1; Pref; Pref1; Pref-1; Prote
Cat:
SL4556R-FITC
Species Reactivity:
Rat,(predicted: Human,Mouse,Rabbit,Sheep,)
Immunogen:
KLH conjugated synthetic peptide derived from sheep DLK1
Format:
Lyophilized or Liquid
Storage instructions:
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration:
1mg/ml
Clonality:
Polyclonal
Isotype:
IgG
Applications:
IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host:
Rabbit
Calculated MW:
42kDa
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Unit:
Price: $
Product PDFs
Datasheet:


background:
This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass. [provided by RefSeq, Mar 2010].

Function:
May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation.

Subunit:
Monomer.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Highly expressed in fetal liver, placenta, adult adrenal gland, brain, testis and ovary and, to a lesser degree, in adult kidney, muscle, thymus and heart.

Post-translational modifications:
N- and O-glycosylated.

Similarity:
Contains 6 EGF-like domains.

Database links:

Entrez Gene: 641301 sheep

Entrez Gene: 281117 Cow

Entrez Gene: 8788 Human

Entrez Gene: 13386 Mouse

Entrez Gene: 114587 Rat

Omim: 176290 Human

SwissProt: P80370 Human

SwissProt: Q09163 Mouse

Unigene: 533717 Human

Unigene: 157069 Mouse

Unigene: 14547 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

穿膜蛋白DLK1又称肝癌相关基因,是表皮生长因子(EGF)家族的成员之一,其结构特征为蛋白的细胞外区域拥有在结构及氨基酸序列上与表皮生长因子高度同源的重复结构.DLK1可以抑制脂肪前体细胞向脂肪细胞分化,在正常神经内分泌细胞及其肿瘤细胞中表达, DLK1在神经内分泌轴中起着调控细胞生长分化的作用,同时DLK1在胚胎肝、造血干细胞及早期肌肉组织中均有表达。
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