background:
The RING finger family of proteins possess ubiquitin ligase activity and play pivotal roles in protein degradation and receptor-mediated endocytosis. The autoubiquitination activity of ZNF364 indicates that it is a novel RING-type E3 ligase. Its effects on cell growth indicate that ZNF364 may be important for the ubiquitin modification of proteins crucial to breast carcinogenesis and growth.
Function:
Acts as an E2-dependent E3 ubiquitin-protein ligase. May be involved in endocytic trafficking.
Subunit:
Interacts with RAB7A.
Subcellular Location:
Cytoplasm, cytosol (By similarity). Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes (By similarity).
Tissue Specificity:
Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells.
Post-translational modifications:
RING-type zinc finger-dependent and E2-dependent autoubiquitination.
Similarity:
Contains 1 RING-type zinc finger.
Database links:
Entrez Gene: 101060478 Human
Entrez Gene: 27246 Human
Entrez Gene: 67845 Mouse
Entrez Gene: 362002 Rat
SwissProt: Q9Y4L5 Human
SwissProt: Q9D0C1 Mouse
Unigene: 523550 Human
Unigene: 386792 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
