background:
Tissue specificity: Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and kidney. Strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. Overexpresseed in 80% of colorectal cancers.
Subunit:
Binds DNA. Interacts with SUMO conjugating enzyme UBC9/UBE2I. Interacts with the telomeric protein TERF2IP.
Subcellular Location:
Nucleus.
Tissue Specificity:
Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and kidney. Strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. Overexpressed in 80% of colorectal cancers.
Post-translational modifications:
Sumoylated.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 10 C2H2-type zinc fingers.
Database links:
Entrez Gene: 100138954 Cow
Entrez Gene: 282395 Cow
Entrez Gene: 7705 Human
Entrez Gene: 26465 Mouse
Entrez Gene: 677248 Mouse
Omim: 601505 Human
SwissProt: Q28151 Cow
SwissProt: Q15072 Human
SwissProt: Q8BQN6 Mouse
Unigene: 643436 Human
Unigene: 446516 Mouse
Unigene: 456449 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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