Rabbit Anti-SOX11/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-SOX11/FITC Conjugated antibody

SRY (sex determining region Y) box 11; SRY related HMG box gene 11; Transcription factor SOX-11; SOX11_HUMAN.

Cat:

SL6736R-FITC

Species Reactivity：

Human,Rat,(predicted: Mouse,Pig,Cow,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human SOX11

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

47kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 and SOX3 show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse (Collignon et al., 1996). These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution. SOX11 appears to be important in the developing nervous system (SOX11 expression is detected from 8.5 dpc through to 13.5 dpc, with a considerable increase in expression by 13.5 dpc). SOX11 expression is apparent in the somites,limbs,facial mesenchyme,kidney,lung of the fetal system.

Function:
Transcriptional activator.

Subcellular Location:
Nucleus.

Tissue Specificity:
Mainly expressed in the developing central nervous system.

Similarity:
Contains 1 HMG box DNA-binding domain.

Database links:

Entrez Gene: 6664 Human

Entrez Gene: 20666 Mouse

Entrez Gene: 16846 Rat

Omim: 600898 Human

SwissProt: P35716 Human

SwissProt: Q7M6Y2 Mouse

SwissProt: P0C1G9 Rat

Unigene: 432638 Human

Unigene: 41702 Mouse

Unigene: 466344 Mouse

Unigene: 162854 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall