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Rabbit Anti-MAPK organizer 1/FITC Conjugated antibody
background:
This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Function:
Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing.
Subunit:
Interacts with EGLN3/PHD3. Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, LAMTOR3, ARAF/Raf-1, MAPK1/ERK2 and MAPK3/ERK1. Identified in the spliceosome C complex.
Subcellular Location:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear.
Similarity:
Belongs to the WD repeat MORG1 family.
Contains 7 WD repeats.
Database links:
Entrez Gene: 84292 Human
Entrez Gene: 67836 Mouse
Entrez Gene: 288924 Rat
SwissProt: Q9BRX9 Human
SwissProt: Q9DAJ4 Mouse
SwissProt: Q5BLX8 Rat
Unigene: 657204 Human
Unigene: 334136 Mouse
Unigene: 3570 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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